General Information

  • ID:  hor000321
  • Uniprot ID:  P41841
  • Protein name:  Met-callatostatin
  • Gene name:  NA
  • Organism:  Calliphora vomitoria (Blue bottle fly) (Musca vomitoria)
  • Family:  Allatostatin family
  • Source:  animal
  • Expression:  Neurons within brain and abdominal ganglion.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Calliphora (genus), Calliphorinae (subfamily), Calliphoridae (family), Oestroidea (superfamily), Calyptratae, Schizophora, Cyclorrhapha, Eremoneura, Muscomorpha (infraorder), Brachycera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  PYDFGM
  • Length:  6(3-8)
  • Propeptide:  GPPYDFGM
  • Signal peptide:  NA
  • Modification:  T1 Hydroxyproline;T6 Methionine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  May act as a neurotransmitter or neuromodulator and play a role in the integration of information within the brain. May be involved in the control of visceral muscles due to its ability to behave as potent inhibitors of peristaltic movements. May also ful
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000321_AF2.pdbhor000321_ESM.pdb

Physical Information

Mass: 81818 Formula: C34H44N6O10S
Absent amino acids: ACEHIKLNQRSTVW Common amino acids: DFGMPY
pI: 3.75 Basic residues: 0
Polar residues: 2 Hydrophobic residues: 1
Hydrophobicity: -35 Boman Index: -259
Half-Life: >20 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: ? Aliphatic Index 0
Instability Index: 3523.33 Extinction Coefficient cystines: 1490
Absorbance 280nm: 298

Literature

  • PubMed ID:  7480873
  • Title:  Modifications of the Blowfly Neuropeptide Met-callatostatin